diff -dupr a/setup.py b/setup.py
--- a/setup.py	2021-02-09 13:49:46.356455141 +0100
+++ b/setup.py	2021-02-09 13:50:49.351076275 +0100
@@ -367,13 +367,15 @@ ext_modules = [
         sources=["src/CAST.c"],
         py_limited_api=True),
     Extension("Crypto.Cipher._raw_des",
-        include_dirs=['src/', 'src/libtom/'],
+        include_dirs=['src/'],
         sources=["src/DES.c"],
-        py_limited_api=True),
+        py_limited_api=True,
+        extra_link_args=["-ltomcrypt"]),
     Extension("Crypto.Cipher._raw_des3",
-        include_dirs=['src/', 'src/libtom/'],
+        include_dirs=['src/'],
         sources=["src/DES3.c"],
-        py_limited_api=True),
+        py_limited_api=True,
+        extra_link_args=["-ltomcrypt"]),
     Extension("Crypto.Util._cpuid_c",
         include_dirs=['src/'],
         sources=['src/cpuid.c'],
@@ -410,9 +412,10 @@ ext_modules = [
         sources=["src/ARC4.c"],
         py_limited_api=True),
     Extension("Crypto.Cipher._Salsa20",
-        include_dirs=['src/', 'src/libtom/'],
+        include_dirs=['src/'],
         sources=["src/Salsa20.c"],
-        py_limited_api=True),
+        py_limited_api=True,
+        extra_link_args=["-ltomcrypt"]),
     Extension("Crypto.Cipher._chacha20",
         include_dirs=['src/'],
         sources=["src/chacha20.c"],
Only in b: setup.py.orig
Only in b: setup.py.rej
diff -dupr a/src/DES.c b/src/DES.c
--- a/src/DES.c	2021-02-09 13:49:46.336454729 +0100
+++ b/src/DES.c	2021-02-09 13:50:02.640123617 +0100
@@ -39,7 +39,7 @@ FAKE_INIT(raw_des3)
 
 /* Include the actial DES implementation */
 #define LTC_NO_PROTOTYPES
-#include "libtom/tomcrypt_des.c"
+#include <tomcrypt.h>
 
 struct block_state {
     symmetric_key sk;